In November 2011, Boris Nikolic forwarded Epstein the landmark Mayo Clinic paper on senescent cell clearance — mice engineered to destroy zombie cells showed delayed cataracts, preserved muscle, and youthful body composition. Epstein's response: "LOVE how it starts 'Memo to mature, health-minded vampires'... Jee was right all along!!!!!" This paper launched the entire field of senolytics.
Barry Josephson wrote Epstein: "All you need is a blood transfusion from the pack and you reverse aging!!" Tony Wyss-Coray's Stanford lab had demonstrated that young blood plasma reversed cognitive decline in aged mice — work that launched Alkahest.
In October 2017, a curated list of 17 scientists was prepared for Epstein — covering parabiosis (Wyss-Coray), stem cells (Weissman), memory implants (Berger), mitochondrial transplants (McCully), epigenome programming (Gersbach), and hyperbaric medicine (Efrati). Budget codes accompanied each entry.
