Re: From wikipedia...
Are the ears - Flowers. Wax coating small hairs
On Mon, Jun 19, 2017 at 2:12 Als wrote:
I went through this list of protein aggregation diseases or proteopathies ... or what I'm calling aggregopathies. It's not a problem with the protein, it's a problem be they aggregate. Anyway, I just did a basic search of all of the names and checked to see if there was evidence for change in intracellular PH with all...yup/not all are in neurons. Weird = this is what happens when you acidify the soil.
| Proteopathy | Major aggregating protein |
|---|---|
| Alzheimer's disease [16] | Amyloid ẞ peptide (AB); Tau protein (see tauopathies) |
| Cerebral ẞ-amyloid angiopathy [49] | Amyloid ẞ peptide (Aẞ) |
| Retinal ganglion cell degeneration in glaucoma [50] | Amyloid ẞ peptide (Aẞ) |
| Prion diseases (multiple)[51] | Prion protein |
| Parkinson's disease and other synucleinopathies (multiple)[52] | a-Synuclein |
| Tauopathies (multiple)[53] | Microtubule-associated protein tau (Tau protein) |
| Frontotemporal lobar degeneration (FTLD) (Ubi+, Tau-)[54] | TDP-43 |
| FTLD-FUS [54] | Fused in sarcoma (FUS) protein |
| Amyotrophic lateral sclerosis (ALS) [55] [56] | Superoxide dismutase, TDP-43, FUS, C9ORF72, ubiquilin-2 (UBQLN2) |
| Huntington's disease and other trinucleotide repeat disorders (multiple)[57] [58] | Proteins with tandem glutamine expansions |
| Familial British dementia [49] | ABri |
| Familial Danish dementia [49] | ADan |
| Hereditary cerebral hemorrhage with amyloidosis (Icelandic) (HCHWA-1) [49] | Cystatin C |
| CADASIL [59] | Notch3 |
| Alexander disease [60] | Glial fibrillary acidic protein (GFAP) |
| Seipinopathies [61] | Seipin |
| Familial amyloidotic neuropathy, Senile systemic amyloidosis | Transthyretin [62] |
| Serpinopathies (multiple)[63] | Serpins |
| AL (light chain) amyloidosis (primary systemic amyloidosis) | Monoclonal immunoglobulin light chains [62] |
EFTA01043156
| AH (heavy chain) amyloidosis | Immunoglobulin heavy chains [62] |
| AA (secondary) amyloidosis | Amyloid A protein [62] |
| Type II diabetes [64] | Islet amyloid polypeptide (IAPP; amylin) |
| Aortic medial amyloidosis | Medin (lactadherin) [62] |
| ApoAl amyloidosis | Apolipoprotein Al[62] |
| ApoAll amyloidosis | Apolipoprotein All[62] |
| ApoAIV amyloidosis | Apolipoprotein AIV[62] |
| Familial amyloidosis of the Finnish type (FAF) | Gelsolin [62] |
| Lysozyme amyloidosis | Lysozyme [62] |
| Fibrinogen amyloidosis | Fibrinogen [62] |
| Dialysis amyloidosis | Beta-2 microglobulin [62] |
| Inclusion body myositis/myopathy[65] | Amyloid ẞ peptide (AB) |
| Cataracts [66] | Crystallins |
| Retinitis pigmentosa with rhodopsin mutations [67] | rhodopsin |
| Medullary thyroid carcinoma | Calcitonin [62] |
| Cardiac atrial amyloidosis | Atrial natriuretic factor [62] |
| Pituitary prolactinoma | Prolactin [62] |
| Hereditary lattice corneal dystrophy | Keratoepithelin [62] |
| Cutaneous lichen amyloidosis [68] | Keratins |
| Mallory bodies [69] | Keratin intermediate filament proteins |
| Corneal lactoferrin amyloidosis | Lactoferrin [62] |
| Pulmonary alveolar proteinosis | Surfactant protein C (SP-C) [62] |
| Odontogenic (Pindborg) tumor amyloid | Odontogenic ameloblast-associated protein [62] |
| Seminal vesicle amyloid | Semenogelin [62] |
| Apolipoprotein C2 amyloidosis | Apolipoprotein C2 (ApoC2)[62] |
| Apolipoprotein C3 amyloidosis | Apolipoprotein C3 (ApoC3) [62] |
| Lect2 amyloidosis | Leukocyte chemotactic factor-2 (Lect2)[62] |
| Insulin amyloidosis | Insulin [62] |
| Galectin-7 amyloidosis (primary localized cutaneous amyloidosis) | Galectin-7 (Gal7)[62] |
| Corneodesmosin amyloidosis | Corneodesmosin[62] |
| Enfuvirtide amyloidosis [70] | Enfuvirtide [62] |
| Cystic Fibrosis [71] | cystic fibrosis transmembrane conductance regulator (CFTR) protein |
| Sickle cell disease [72] | Hemoglobin |
please note
The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE
Unauthorized use, disclosure or copying of this
EFTA01043157
communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevacation@gmail.com, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved
EFTA01043158