Monthly Update and Offers
No more itch
New preventive strategies for atopic dermatitis are made possible with the discovery that mutations in the filaggrin gene are associated with the disease. F1000 Report by Hywel C Williams, Joanne R Chalmers and Eric L Simpson.
New plant species via only two mutations
Tremendous recent advances in molecular genetics have made it clear that new plant species can evolve via two or more mutational steps, as is predicted by the Dobzhansky-Muller model. F1000 Report by Andrea L. Sweigart and John H. Willis.
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Open Repository for posters and slide presentations. Recommended poster of the month -- Urology: Sexual self-consciousness in a sample of men and women with and without sexual difficulties: an exploratory study.
RESEARCH ARTICLE
ALS-linked SOD1 in glial cells enhances β-N-Methylamino L-Alanine (BMAA)-induced toxicity in Drosophila. Published: 9 Nov 2012. Rafique Islam, Emily L Kumimoto, Hong Bao, Bing Zhang. F1000 Research 1:47.
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Some of the articles that caught the attention of our F1000 Faculty this month.
Building thyroid from scratch
The authors elegantly demonstrate that stem cells can be specifically reprogrammed to generate a functioning thyroid gland replacement.
Casting the neutrophil NETs wide
This study highlights the multi-potent functional abilities of neutrophils in combatting bacterial infections by casting neutrophil extracellular traps (NETs).
Colorectal cancer, an inflammatory issue
A four-times-recommended study elucidates how microbiota composition can affect the development of colitis-associated cancer and vividly distinguishes genotoxicity and carcinogenicity from inflammation.
Alzheimer's hidden signs
Presents clear evidence that the biochemical pathways thought to lead to Alzheimer's disease can precede symptoms by more than 20 years.
Tubulin, pure and simple
The authors have developed new method of purifying tubulin from different eukaryotic sources that make it possible to conduct in vitro reconstitution experiments with much greater physiological relevance.
Solid trials, solid medicine
The ALTITUDE study (Aliskiren trial in type 2 diabetes using cardiorenal endpoints) underlines the critical importance of suitably powered trials with hard clinical endpoints in informing evidence-based treatments for patients.
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