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Homechevron_right Emailchevron_right Re: value
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Re: value

5 messages picture_as_pdf Source PDF
J
jeffrey E. Jul 10, 2014 8:07 AM
To
george church

I have a great idea. lets speak today if possible
please note
The information contained in this communication is
confidential, may be attorney-client privileged, may
constitute inside information, and is intended only for
the use of the addressee. It is the property of
JEE
Unauthorized use, disclosure or copying of this

Unauthorized use, disclosure or copying of this

EFTA_R1_00357161
EFTA01917109

communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jeevaeation@gmail com and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved

please note

The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use ofthe addressee. It is the property of JEE

Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to icevacationatemail.com and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved

please note

The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE

Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to jccvacationQi)tzmail.com and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved

G
george church Jul 11, 2014 5:04 PM
To
jeffrey E.

Jeffrey,

  • Many thanks for your very encouraging words yesterday morning. This is already a super interesting experiment (even with $0 spent), since I am looking at my whole ecosystem of companies and unassigned inventions totally differently. Eye-opening to see how accustomed one can become to the assumptions, whims and rules of VCs. For example, investors starting Hclicos took Eric's advice over mint in 2003 (even though he had zero sequencing technology invention experience and I had 26 years) -- so rather than a large founder's share in a new company (Helicos), my technology dribbled into an established company (CGI) from 2006-2012. CGI was sold for $1 17M in 2012, while Helicos went bankrupt.

  • Below is a first pass list ofpotential investments for the SIOM. This may be more information than you wanted at this point (especially given the trade-off between jargon and brevity), but I'm having so much fun, I just wanted to share it. Fm also recording a few extra thoughts, in case they provide "teaching moment" or post-mortem at some point.

$200,000 Supercentenarianstudy.com
$1,500,000 eGenesisBio.com
$1,000,000 Sensor-Selectors
$1,000,000 Protein stability & virus resistance
$1,000,000 Pest control
$800,000 Aging reversal
$1,550,000 Next generation pathology
$250,000 Space Genetics
$200,000 Cold-resistant elephants
$2,500,000 2nd tranche

Total

EFTA_R1_00357160
EFTA01917108

$10,000,000

  1. Supercentenarianstudy.com Thirty genomes collected so far on a small budget by James Clement. $200K would get 8% ownership of the company and allow another 30 gcnomes to be collected, sequenced and therapies patented.

  2. eGenesisBio.com: Using CRISPR to engineer animals for resistance to infectious diseases and to act as transplantation donors for major organs (initially kidneys) to humans. Co-founded with Prashant Mali and Luhan Yang. Already has a couple of contracts and a some rented lab space.

  3. Sensor-selector technology for optimizing commercial production of (bio)chemicals. Lead by Vatsan Raman.

  4. Multi-virus-resistant New Sox-insensitive organisms. We just protein published cross linking papers based and patents on radically on this. recoded Lead by bacterial Dan Mandell. genomes and/or

  5. Eliminating ecosystem pests and invasive species. Lead by Kevin Esvelt. This will probably be in the news on July 17. Business model similar to the relationship between Amyris and the Gates Foundation for manufacturing anti-malaria drugs.

  6. Making human genetic disease models in organoids and aging reversal using CRISPR and other epigenetic reprogramming factors. Lead by Bobby Dhadwar and Eswar lyer. Possibly mergeable with Supercentenarianstudy.com

  7. A new sequencing method capable of displacing part of the medical pathology imaging market and filling in the large gaps in most plant and animal genome sequences. Lead by Rich Terry.

  8. Genome engineering of humans for space. Seed money for patent fees, some lab tests and education efforts via pgEd. Lead by Ting Wu.

  9. Making cold-resistant elephants via CRISPR, focusing on blood, subcutaneous fat and wool/hair (based on what is know about cold-resistant animals, Mammoth DNA, and human mutations). Economics could be like the American Bison which recently grew from a hundred to 500,000 as a source of low cholesterol meat. Lead by Margo Monroe and Justin Quinn. Possibly mergeable with EgenesisBio.

  10. The rest would be set aside as a second tranche for whichever of the above efforts makes best progress first.

--George

J
jeffrey E. Jul 13, 2014 11:26 AM
To
george church

speak or skype today>?

G
george church Jul 13, 2014 11:38 AM
To
jeffrey E.

Sure. My Skype is ███████ and my cell is ██████████
--Geo

J
jeffrey E. Jul 13, 2014 4:40 PM
To
george church

2?

On Sun, Jul 13, 2014 at 11:38 AM, george church <███████████> wrote:

Sure. My Skype is ███████ and my cell is ██████████
--Geo

From: "jeffrey E." jeevacation@gmail.com
Date: Sunday, July 13, 2014 at 11:26 AM
To: george church <>
Subject: Re: value

speak or skype today>?

1419 files from the DOJ Epstein case media release. All files are public records from justice.gov.

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