To: jeeyacationftmaitcomijeeyacation@gmaitcom]; Epstein Jeftreybeevacation©gmail corn] From: Lesley Groff Sent Thur 8/1/2013 12:39:53 PM Subject: Dr Joe Thakuria Sent from my iPhone Begin forwarded message: From: Joseph Thakuria Date: August I, 2013 8:03:44 AM EDT To: Lesley Groff Cc: "Dr. George Church" Subject: Re: Jeffrey Epstein Hi Lesley, Jeffrey's skin biopsy resulted in several successful, viable fibroblast cultures. Those cell lines are now stored in liquid nitrogen and slated for iPS cell line ("adult stem cells") creation. Essentially, this process requires several culture passages, and reiteration of picking out the right colony for further passages. Success rate of generating iPS cells is relatively high now but the process still takes several months. On the DNA side of things, I'm working on getting Jeffrey's sample into the current queue. If it makes it, we're probably looking at about 2 months turnaround time until whole genome data. Let nu: know if I can help with other questions. Best. Joe Joseph V. Thakuria, MD, MMSc Medical Genetics and Metabolism Attending Physician Director, MGH Stickler Syndrome Program Medical Director, Personal Genome Project Harvard Catalyst CRC Protocol Review Committee MGH Center for Human Genetics Research Massachusetts General Hospital 185 Cambridge St., Rm. 2222 Boston Office Fax: email: The information in this e-mail is is ntended only for the person to whom it EFTA_R1_02204060 EFTA02720568 addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.orq/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. On Thu, Aug 1, 2013 at 7:43 AM, Lesley Groff wrote: Good morning George and Joe. Jeffrey requested I check in and see how things are progressing with his genomc. Could you please advise? Thank you, Lesley Assistant to Jeffrey Epstein Sent from my iPhone EFTA_R1_02204061 EFTA02720569