1d chg (%) Index. WI (%) BIOGEN IDEC INC -8.2 7.9 AMGEN INC -3.2 7.8 Gil F • n SCIENCES INC. -4.6 7.0 REGENERON PHARMACEUTICALS -5.4 6.9 CELGENE CORP -3.7 6.5 ALEXION PHARMACEUTICALS INC -8.0 4.6 ILLUMINA INC -5.4 4.6 MYLAN INC -0.9 4.3 VERTEX PHARMACEUTICALS INC -5.1 3.8 BIONMIN PHARMACEUTICAL INC -5.9 2.5 Ways to hedge exposure to the US biotech sector • ProShares UltraShort Nasdaq Biotech Fund (BIS US Equity): designed to be 2x short the NBI • Options on iSharesNasdaq Biotech ETF (IBB US Equity) NBI — last 5 ears 2009 2010 2011 2012 300u 2577.21 2000 1500 1000 500 2013 201, N kaccaq BlOteCh^t 'J4:4 Copyrighte 2014 alccenterg Finance L.V. 23-Mar-2014 14:3S:20 NBI vs S&P500 — last 1 year Normalized As Of 03/23/2013 o• NBI Index - SPX Index 38..8807 i s Jun NBI — last 1 year Sep Dec Mar 2013 2014 60 " )8.8807 20 • 0 CONFIDENTIAL - PURSUANT TO FED. R. CRIM. P. 6(e) DB-SDNY-0 111026 CONFIDENTIAL SDNY_GM_00257210 EFTA01453444