3000 2577.21 2000 1500 1000 500 2009 2010 2011 2012 I 2013 2014 NBI Index (Nasdaq Biotednotogy Index) Copyright@ 2014 Bloomberg Finance L.P. 2344er-2014 14:35:20 CONFIDENTIAL - PURSUANT TO FED. R. CRIM. P. 6(e) DB-SDNY-0110985 CONFIDENTIAL SDNY_GM_00257169 EFTA01453417